Pesquisa sobre:
GRB2 ADAPTOR PROTEIN
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DeCS
Descritor
Inglês
:
GRB2 Adaptor Protein
Descritor
Espanhol
:
Proteína Adaptadora GRB2
Descritor
Português
:
Proteína Adaptadora GRB2
Sinônimos
Inglês
:
Growth Factor Receptor-Bound Protein-2
Categoria:
D12.644.360.024.297
D12.776.157.057.026
D12.776.476.024.377
Definição
Inglês
:
A signal transducing adaptor protein that links extracellular signals to the
MAP KINASE SIGNALING SYSTEM
. Grb2 associates with activated
EPIDERMAL GROWTH FACTOR
RECEPTOR and
PLATELET-DERIVED GROWTH FACTOR
RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the
SON OF SEVENLESS PROTEINS
through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
Nota Histórica
Inglês
:
2006(1992)
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
50766
Identificador Único:
D051380
Ocorrência na BVS
:
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CID-10
SciELO
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